Education:

Ph.D., Tongji Medical College, Huazhong University of Science and Technology, China, 2002;
M. D., Tongji Medical University, China 1999


Research Interest:

NAADP-mediated calcium signaling pathway; Pathophysiology of lysosome dysfunction; NAD(P)H oxidase related redox signaling and pathobiology; Transient Receptor Potential (TRP)-ML channel function. 
 

Selected Publications:

Zhang F, Jin S, Yi F, Li PL. TRP-ML1 Functions as a Lysosomal NAADP-Sensitive Ca2+ Release Channel in Coronary Arterial Myocytes. J Cell Mol Med. 2008 Aug 27. [Epub ahead of print]

Zhang F, Jin S, Yi F, Xia M, Dewey WL, Li PL. Local production of O2˙ˉ by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal. 2008 Apr;20(4):637-44.

Zhang F, Li PL. Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats. J Biol Chem. 2007 Aug 31;282(35):25259-69.

Zhang F, Zhang G, Zhang AY, Koeberl MJ, Wallander E, Li PL. Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes. Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H274-82.

Zhang F, Siow YL, O K. Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney. Kidney Int. 2004 Apr;65(4):1327-38.